Keloids are abnormally healed skin wounds that develop in the subcapillary layer of the dermis. It had been defined clinically as a raised dermal lesion which extends beyone the boundaries of the original wound and frequently recurs after excision.
To study the possible relationship of the immune system to keloid formation, we examined immunoglobulins and complements of the human serum. IgM, IgG, IgA, C₃ ＆C₄ levels were quantitated in whole human serum by the use of the radial immunodiffusion(Mancini test).
All the individuals in this study are the patients of 22 keloids and 60 normal control group. The keloic groups consisted of 17 females and 5 males with the mean age of 17±2.4 years, while the control group consists of 32 females and 28 males with mean age of 23±2.7 years.
The results are obtained as follows:
Serum IgM level was significantly higher in the keloid group than in the control group, while serum IgA level was high in the control group than in the keloid group. IgG, C₃ & C₄ levels were essentially the same in the both groups.
But, above results could not be differentiate that the patients have keloid tendency or not. So, further investigation about immune reaction was proposed.
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